AB0575 FACTORS ASSOCIATED WITH PSORIATIC ARTHRITIS ACTIVITY IN CLINICAL PRACTICE

Background: Psoriatic Arthritis (PsA) is a multifaceted disease with various clinical domains. A number of composite indices has been developed recently [1, 2]. DAPSA ( D isease ctivity in PS oriatic rthritis) the valid instrument for assessment PsA activity focused on peripheral arthritis. But other factors can influence and haven’t studied yet. Objectives: to identify that are associated based data from RU-PsART cohort. Methods: 117 (M/F=63(54%)/54(46%)) patients (pts) active fulfilling CASPAR criteria mean age 44.3 ± 10.9 yrs, 37.8±21.4, duration 73.4±78.4 mo, PsO 213.4±152.5 were included. Data was collected 43 rheumatology centers Russian Federation. All pts underwent standard examination at enrollment. DAPSA, ESR (mm/h), CRP (mg/L), dactylitis, enthesitis by LEI plus Plantar Fascia, BSA (%), HAQ-DI fatigue Fatigue Scale (V.4) FACIT (Functional Assessment Chronic Illness Therapy), BMI (kg/m 2 ) evaluated. > 28 indicate high activity. Multi-dimensional step-by-step discriminant analysis used group features DAPSA. M±SD, %, OR 95% (CI) performed. Results: The following proved be most informative: (p=0.739), tenderness Fascia (p=0.003), (p=0.0004), (p=0.092), >2 yrs (p=0.013), BSA>3% (p=0.021), Nail (p=0.22). area under ROC-curve (AUC) 0.768, CI (0.624-0.913). Sensitivity/ Specificity model 77.0%/ 69% accordingly (Figure 1). Figure 1 ROC Sensitivity model. Conclusion: Weight, enthesitis, skin nail severity, as well articular symptoms. New combination these should validated practice. References: [1]Helliwell P, et al. development candidate responder psoriatic arthritis (GRACE project). Ann Rheum Dis. 2013; 72: 986-91. doi: 10.1136/annrheumdis-2012-201341. [2]Salaffi F, Disease Activity Arthritis: Comparison Discriminative Capacity Construct Validity Six Composite Indices Real World. BoiMed Res Int 2014; 2014:52805 http://dx.doi.org/10.1155/2014/528105 Disclosure Interests: None declared.